Controversial Role of Gamma-Glutamyl Transferase Activity in Cisplatin Nephrotoxicity
نویسندگان
چکیده
منابع مشابه
Controversial role of gamma-glutamyl transferase activity in cisplatin nephrotoxicity.
Nephrotoxicity of chemotherapeutics is a major hindrance in the treatment of various tumors. Therefore, test systems that reflect mechanisms of human kidney toxicity are necessary, and to reduce animal testing cell culture based systems have to be developed. One cell type that is of specific interest in this regard are renal proximal tubular epithelial cells, as they reabsorb substances from hu...
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In view of data suggesting that deficiency of gamma glutamyl transferase (GGT) may be the primary abnormality in the small-intestinal mucosa of patients with coeliac disease, this enzyme was measured in mucosal biopsies from coeliac patients at different stages of treatment. Activity was only slightly reduced in only one of nine well-treated patients, suggesting that deficiency of this enzyme h...
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BACKGROUND: Urinary oxalate and citrate are the keyfactors in caox urolithiasis of cats and Gamma GlutamylTransferase is a good test for assessment of kidney damage.Favorable effects of Cynodon dactylon on calcium oxalate stoneformation have recently been proved in rats. OBJECTIVES: Thepresent study was designed to investigate the alteration ofurinary oxalate, citrate, and GGT after administrat...
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ژورنال
عنوان ژورنال: ALTEX
سال: 2014
ISSN: 1868-596X
DOI: 10.14573/altex1311152